The science of bio-remulation for Executable Organ on Chips
Abstract — The use of simulation models in biology is extensively studied. Emulation is used, in contrast to simulation, when a controller (such as a pacemaker) for a biological process (the heart) needs validation in real-time. Here, the pacemaker is connected in closed-loop with a living heart. This may occur either during the clinical trial phase with human subjects
or animal models. We argue that such emulation is expensive, time limiting, and has associated ethical considerations. We propose the science of remulation (reverse-emulation) as an alternative paradigm. Here, we develop executable models of the biological process (say the cardiac conduction system) that is realisable on a reprogrammable computer chip, called Field Programmable Gate Array (FPGA).
Such an ``Executable Organ on Chip'' (ExOoC) provides high-fidelity and real-time capabilities like a real heart, from the point of view of the pacemaker. Remulation of such ``Executable Organ on Chip'' (ExOoC) has not only excellent potential for medical device validation and certification but also can be used for personalisation and non-invasive diagnostics.
We have developed the first high-fidelity remulation model of the cardiac conduction system and have used this to validate a pacemaker in real-time.
Partha Roop is Associate Professor of Computer Systems Engineering in the University of Auckland, New Zealand. His research interests are: Real-Time Systems, Executable Biology, Medical Devices, Industrial Informatics, and Embedded Systems. Partha is an Associate Editor of IEEE Embedded Systems Letters and Springer / Eurasip journal on embedded systems. Partha received Humboldt Fellowship for experienced researchers (2009) and Mercator Professorship from the German Research Council, DFG (2016).
Mobile: +64 9 923 5583